| 1 | Sebastian Driussi
Austin FC | Austin FC | 37 | 25 |
| 2 | Dániel Gazdag
Philadelphia Union | Philadelphia Union | 37 | 24 |
| 3 | Hany Mukhtar
Nashville SC | Nashville SC | 34 | 23 |
| 4 | Brandon Vazquez
FC Cincinnati | FC Cincinnati | 35 | 19 |
| 5 | Brenner Souza da Silva
FC Cincinnati | FC Cincinnati | 31 | 18 |
| - | Cristian Daniel Arango Duque
Los Angeles FC | Los Angeles FC | 37 | 18 |
| - | Javier Hernández
LA Galaxy | LA Galaxy | 34 | 18 |
| - | Jesús Ferreira
FC Dallas | FC Dallas | 35 | 18 |
| 9 | Jeremy Ebobisse
San Jose Earthquakes | San Jose Earthquakes | 34 | 17 |
| 10 | Gonzalo Higuaín
Inter Miami CF | Inter Miami CF | 29 | 16 |
| - | Diego Rubio
Colorado Rapids | Colorado Rapids | 30 | 16 |
| 12 | Rommel Quioto
CF Montréal | CF Montréal | 31 | 15 |
| - | Julian Carranza
Philadelphia Union | Philadelphia Union | 34 | 15 |
| - | Lewis Morgan
New York Red Bulls | New York Red Bulls | 33 | 15 |
| 15 | Valentín Castellanos
New York City FC | New York City FC | 17 | 13 |
| - | Mikael Uhre
Philadelphia Union | Philadelphia Union | 30 | 13 |
| - | Sebastián Ferreira
Houston Dynamo | Houston Dynamo | 31 | 13 |
| 18 | Dejan Joveljic
LA Galaxy | LA Galaxy | 34 | 12 |
| - | Taxiarchis Fountas
D.C. United | D.C. United | 21 | 12 |
| - | Carlos Vela
Los Angeles FC | Los Angeles FC | 35 | 12 |
| 21 | Leonardo Campana
Inter Miami CF | Inter Miami CF | 26 | 11 |
| - | Ercan Kara
Orlando City SC | Orlando City SC | 30 | 11 |
| - | Djordje Mihailovic
CF Montréal | CF Montréal | 29 | 11 |
| - | Sergio Cordova
Real Salt Lake | Real Salt Lake | 34 | 11 |
| - | Emanuel Reynoso
Minnesota United FC | Minnesota United FC | 30 | 11 |
| - | Luciano Acosta
FC Cincinnati | FC Cincinnati | 32 | 11 |
| 27 | Heber Araujo
New York City FC | New York City FC | 32 | 10 |
| - | Dairon Estibens Asprilla Rivas
Portland Timbers | Portland Timbers | 29 | 10 |
| - | Gyasi Zerdes
Colorado Rapids | Colorado Rapids | 26 | 10 |
| - | Lucas Zelarrayan
Columbus Crew SC | Columbus Crew SC | 29 | 10 |
| - | Karol Swiderski
Charlotte FC | Charlotte FC | 30 | 10 |
| - | Paul Arriola
FC Dallas | FC Dallas | 34 | 10 |
| 33 | Juan Camilo Hernández Suárez
Columbus Crew SC | Columbus Crew SC | 16 | 9 |
| - | Raúl Ruidíaz
Seattle Sounders | Seattle Sounders | 18 | 9 |
| - | Josef Martínez
Atlanta United FC | Atlanta United FC | 26 | 9 |
| - | Ola Kamara
D.C. United | D.C. United | 30 | 9 |
| - | Lucas Cavallini
Vancouver Whitecaps | Vancouver Whitecaps | 24 | 9 |
| - | Gabriel Pereira
New York City FC | New York City FC | 29 | 9 |
| - | Jonathan Osorio
Toronto FC | Toronto FC | 23 | 9 |
| - | Kaiansu Kamara
CF Montréal | CF Montréal | 34 | 9 |
| - | Jaroslaw Niezgoda
Portland Timbers | Portland Timbers | 30 | 9 |
| - | Derrick Etienne
Columbus Crew SC | Columbus Crew SC | 33 | 9 |
| - | Maximiliano Urruti
Austin FC | Austin FC | 35 | 9 |
| - | Jesus Jimenez Nunez
Toronto FC | Toronto FC | 33 | 9 |
| - | Luis Amarilla
Minnesota United FC | Minnesota United FC | 34 | 9 |
| - | Facundo Torres
Orlando City SC | Orlando City SC | 34 | 9 |
| 47 | William Agada
Sporting Kansas City | Sporting Kansas City | 12 | 8 |
| - | Federico Bernardeschi
Toronto FC | Toronto FC | 13 | 8 |
| - | Cory Burke
Philadelphia Union | Philadelphia Union | 36 | 8 |
| - | Jhon Durán
Chicago Fire | Chicago Fire | 27 | 8 |