| 1 | Carlos Vela
Los Angeles FC | Los Angeles FC | 33 | 36 |
| 2 | Zlatan Ibrahimovic
LA Galaxy | LA Galaxy | 31 | 31 |
| 3 | Josef Martínez
Atlanta United FC | Atlanta United FC | 32 | 28 |
| 4 | Diego Rossi
Los Angeles FC | Los Angeles FC | 36 | 17 |
| 5 | Héber Araújo dos Santos
New York City FC | New York City FC | 23 | 15 |
| - | Chris Wondolowski
San Jose Earthquakes | San Jose Earthquakes | 32 | 15 |
| - | Raúl Ruidíaz
Seattle Sounders | Seattle Sounders | 26 | 15 |
| - | Kacper Przybylko
Philadelphia Union | Philadelphia Union | 26 | 15 |
| 9 | Kaiansu Kamara
Colorado Rapids | Colorado Rapids | 29 | 14 |
| - | Alejandro Pozuelo
Toronto FC | Toronto FC | 34 | 14 |
| 11 | Jordan Morris
Seattle Sounders | Seattle Sounders | 30 | 13 |
| - | Gyasi Zerdes
Columbus Crew SC | Columbus Crew SC | 28 | 13 |
| - | Mauro Andrés Manotas Páez
Houston Dynamo | Houston Dynamo | 32 | 13 |
| - | C.J Sapong
Chicago Fire | Chicago Fire | 32 | 13 |
| 15 | Jozy Altidore
Toronto FC | Toronto FC | 23 | 12 |
| - | Nemanja Nikolic
Chicago Fire | Chicago Fire | 31 | 12 |
| - | Alexandru Mitrita
New York City FC | New York City FC | 30 | 12 |
| - | Nani
Orlando City SC | Orlando City SC | 30 | 12 |
| - | Felipe Gutiérrez
Sporting Kansas City | Sporting Kansas City | 32 | 12 |
| 20 | Brian Fernández
Portland Timbers | Portland Timbers | 19 | 11 |
| - | Diego Rubio
Colorado Rapids | Colorado Rapids | 26 | 11 |
| - | Valentín Castellanos
New York City FC | New York City FC | 31 | 11 |
| - | Jeremy Ebobisse
Portland Timbers | Portland Timbers | 35 | 11 |
| - | Daniel Royer
New York Red Bulls | New York Red Bulls | 32 | 11 |
| - | Wayne Rooney
D.C. United | D.C. United | 29 | 11 |
| - | Pedro Santos
Columbus Crew SC | Columbus Crew SC | 33 | 11 |
| 27 | Adama Diomande
Los Angeles FC | Los Angeles FC | 27 | 10 |
| - | Tesho Akindele
Orlando City SC | Orlando City SC | 28 | 10 |
| - | Carlos Quintero
Minnesota United FC | Minnesota United FC | 31 | 10 |
| - | Albert Rusnák
Real Salt Lake | Real Salt Lake | 31 | 10 |
| - | Carles Gil de Pareja Vicent
New England Revolution | New England Revolution | 35 | 10 |
| 32 | Gustavo Bou
New England Revolution | New England Revolution | 15 | 9 |
| - | Sam Johnson
Real Salt Lake | Real Salt Lake | 26 | 9 |
| - | Christian Ramirez
Houston Dynamo | Houston Dynamo | 10 | 9 |
| - | Alberth Elis
Houston Dynamo | Houston Dynamo | 26 | 9 |
| - | Johnny Russell
Sporting Kansas City | Sporting Kansas City | 28 | 9 |
| - | Jefferson Savarino
Real Salt Lake | Real Salt Lake | 30 | 9 |
| - | Saphir Sliti Taider
CF Montréal | CF Montréal | 32 | 9 |
| - | Nicolás Lodeiro
Seattle Sounders | Seattle Sounders | 32 | 9 |
| 40 | Marco Fabián
Philadelphia Union | Philadelphia Union | 25 | 8 |
| - | Bryan White
New York Red Bulls | New York Red Bulls | 20 | 8 |
| - | Krisztián Németh
Sporting Kansas City | Sporting Kansas City | 24 | 8 |
| - | Orji Okwonkwo
CF Montréal | CF Montréal | 28 | 8 |
| - | Nick DeLeon
Toronto FC | Toronto FC | 36 | 8 |
| - | Fredy Montero
Vancouver Whitecaps | Vancouver Whitecaps | 32 | 8 |
| - | Valeri Kazaishvili
San Jose Earthquakes | San Jose Earthquakes | 32 | 8 |
| - | Jesús Ferreira
FC Dallas | FC Dallas | 34 | 8 |
| - | Diego Valeri
Portland Timbers | Portland Timbers | 32 | 8 |
| - | Julian Gressel
Atlanta United FC | Atlanta United FC | 36 | 8 |
| 50 | Zdenek Ondrášek
FC Dallas | FC Dallas | 18 | 7 |